Sudden death in two patients with epilepsy and the syndrome of inappropriate antidiuretic hormone secretion (siadh)
نویسندگان
چکیده
We report two cases with complex partial and secondarily generalized seizures, both on oxcarbazepine and vigabatrin, with additional lamotrigine in one case. Both died in a manner resembling SUDEP, i.e. suddenly, unexpectedly, probably following a seizure with pulmonary oedema at autopsy. Both had SIADH. A number of drugs may cause SIADH, among them carbamazepine and oxcarbazepine. A search for SIADH in patients on carbamazepine and oxcarbazepine, and in cases of sudden death in epilepsy, is recommended.
منابع مشابه
Psychosis followed by Lung Cancer with Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH): A Case Report
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) refers to the excessive release of antidiuretic hormone (ADH) resulting in water retention, dilutional hyponatremia and urinary sodium waste, and some other clinical manifestations. Causes of SIADH include many disease conditions, some medications and nicotine. The present study reports a case of psychosis followed by lung canc...
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متن کاملSyndrome of inappropriate antidiuretic hormone secretion.
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) results from the aberrant or sustained secretion of the antidiuretic hormone. Classic manifestations include water retention, hyponatremia, and hypo-osmolality of the serum. Treatment is aimed at differentiating SIADH from other causes of hyponatremia, determining the underlying disorder, and alleviating the excessive water re...
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عنوان ژورنال:
- Seizure
دوره 7 شماره
صفحات -
تاریخ انتشار 1998